姓　　名: 黄楚鹰（土家族）；

办公电话:15027234433；

电子邮件:huangchuying_esch@hbmzu.edu.cn；

通讯地址: 湖北省恩施市金龙大道中段88号；

任职情况：博士，恩施州中心医院，副主任医师；

研究领域：肿瘤学、天然产物、中药学；

一、学习和工作简历：

学习经历：

2006.09-2011.07中国医科大学 临床医学 本科

2011.09-2014.07四川大学华西医院住院医师

2015.09-2018.07 湖北民族大学 内科学 硕士研究生

2018.11-2019.12 瑞典KarolinskaInstitutet访问学者

2021.09-2024.07 华中科技大学博士研究生（少数民族骨干计划）

工作经历：

2014.07-2020.12 恩施州中心医院住院医师

2020.01-2021.08 恩施州中心医院主治医师

2024.12-至今 成都中医药大学，博士后（合作导师：陈士林院士）

二、承担科研项目情况：

1、国家自然科学基金项目，双磷酸盐逆转肺腺癌EGFR-TKI 获得性耐药的作用及分子机制研究，项目编号81660503，经费27万元，27万, 2017.1-2020.12，主持。

2、国家自然科学基金项目，EGF/EGFR通过Nrf2通路调控EGFR-TKIs耐药肺癌细胞铁死亡的分子机制研究，项目编号82160490，经费35万元，2021-2025，主持。

三、代表性论文

1. Huang C, Wang L, Wang Y, Yang X, Li Q. Carcinoma showing thymus-like differentiation of the thyroid (CASTLE). Pathol Res Pract. 2013 Oct;209(10):662-5.

2.Zhang Y, Li XY, Tang Y, Xu Y, Guo WH, Li YC, Liu XK, Huang CY, Wang YS, Wei YQ. Rapid increase of serum neuron specific enolase level and tachyphylaxis of EGFR-tyrosine kinase inhibitor indicate small cell lung cancer transformation from EGFR positive lung adenocarcinoma? Lung Cancer. 2013 Aug;81(2):302-5.

3. Wang L, Yang X, Han Z, Huang C. Congenital Ewing's Sarcoma/Primitive Neuroectodermal Tumor of the Upper Extremity. Iran J Pediatr. 2015 Dec;25(6):e3800.

4. Wang L, Huang C, Yang X, Xiao H, Zou L. Primary Angiosarcoma of the Breast with Pulmonary Metastasis. Breast J. 2015 Jul-Aug;21(4):435-7.

5. Li G, He Y, Yao J, Huang C, Song X, Deng Y, Xie S, Ren J, Jin M, Liu H. Angelicin inhibits human lung carcinoma A549 cell growth and migration through regulating JNK and ERK pathways. Oncol Rep. 2016 Dec;36(6):3504-3512.

6.Feng C, Liu X, Li X, Guo F, Huang C, Qin Q, Wang Y. Zoledronic acid increases the antitumor effect of gefitinib treatment for non-small cell lung cancer with EGFR mutations. Oncol Rep. 2016 Jun;35(6):3460-70.

7. Huang CY, Wang L, Feng CJ, Yu P, Cai XH, Yao WX, Xu Y, Liu XK, Zhu WJ, Wang Y, Zhou J, Lu Y, Wang YS. Bisphosphonates enhance EGFR-TKIs efficacy in advanced NSCLC patients with EGFR activating mutation: A retrospective study. Oncotarget. 2016 Oct 11;7(41):66480-66490.

8.Yang X, Gao Y, Liu Q, Wan L, Liu H, Bian W, Du Y, Huang C*. Zoledronic acid re‑sensitises gefitinib‑resistant lung cancer cells by inhibiting the JAK/STAT3 signalling pathway and reversing epithelial‑mesenchymal transition. Oncol Rep. 2021 Feb;45(2):459-468. (IF: 4.136/Q3)

9. Li Y, Kumar PS, Tan S, Huang C, Xiang Z, Qiu J, Tan X, Luo J, He M. Anticancer and antibacterial flavonoids from the callus of Ampelopsis grossedentata; a new weapon to mitigate the proliferation of cancer cells and bacteria. RSC Adv. 2022 Aug 25;12(37):24130-24138. (IF: 3.9/Q2)

10. Huang C*, Ying H, Yang X, Gao Y, Li T, Wu B, Ren M, Zhang Z, Ding J, Gao J, Wen D, Ye X, Liu L, Wang H, Sun G, Zou Y, Chen N, Wang L. The Cardamine enshiensis genome reveals whole genome duplication and insight into selenium hyperaccumulation and tolerance. Cell Discov. 2021 Aug 10;7(1):62. (IF: 38.079/Q1)

11. Mei Yang, Bo Pei, Qiancheng Hu, Xiaoying Li, Xiping Fang, Xue Huang, Zunjing Yang, Jiaquan Chen, He Du, Guogen Sun, Peng Lv, Li Wang, Zixiong Zhang*, Lin Lai*, Chuying Huang*. Effects of selenium supplementation on concurrent chemoradiotherapy in patients with cervical cancer: A randomized, double-blind, placebo-parallel controlled phase II clinical trial. Front. Nutr. 2023,10:1094081. (IF: 6.59/Q1)

12. Li J, Huang C*, Lai L, Wang L, Li M, Tan Y, Zhang T*. Selenium hyperaccumulator plant Cardamine enshiensis: from discovery to application. Environ Geochem Health. 2023 Aug;45(8):5515-5529. (IF:4.9321/Q2)

13. Li M, Yang B, Ju Z, Qiu L, Xu K, Wang M, Chen C, Zhang K, Zhang Z, Xiang S, Zheng J, Yang B, Huang C*, Zheng D*. Do high soil geochemical backgrounds of selenium and associated heavy metals affect human hepatic and renal health? Evidence from Enshi County, China. Sci Total Environ. 2023 Jul 20;883:163717. (IF:10.7/Q1)

14. Cheff DM, Huang C, Scholzen KC, Gencheva R, Ronzetti MH, Cheng Q, Hall MD, Arnér ESJ. The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1. Redox Biol. 2023 Jun;62: 102703. Epub 2023 Apr 17. (IF:10.7/Q1)

15.Chuying Huang*, Yishan Guo, Tuo Li, Guogen Sun, Jinru Yang, Yuqi Wang, Ying Xiang, Li Wang, Min Jin, Jiao Li, Yong Zhou, Bing Han, Rui Huang, Jiao Qiu, Yong Tan, Jiaxing Hu, Yumiao Wei, Bo Wu, Yong Mao, Lingshan Lei, Xiusheng Song, Shuijie Li*, Yongsheng Wang*, Tao Zhang*. Pharmacological activation of GPX4 ameliorates doxorubicin-induced cardiomyopathy, Redox Biol. Redox Biol. Volume70, 2024, 103024, ISSN2213-2317. (IF:11.4/Q1)

16. Guo, Yishan;Huang, Chuying; Zhang, Jiahui; Wang, ZHEN; Guo, Xiaopeng; Wei, YumiaoInjectable Conductive Hydrogel Containing Black Phosphorus Nanosheets Inhibits the Oxidative Stress-Inflammation Chain during Myocardial Infarction, ACS Applied Nano Materials. (IF: 6.14/Q2)

17.Wang H, Zhai M, Li M, Han C, Liu L, Huang C, Zhao L, Yu D, Tao K, Ren J, Lin Z, Zhang T. Phenotypic plasticity and increased infiltration of peripheral blood-derived TREM1⁺ mono-macrophages following radiotherapy in rectal cancer. Cell Rep Med. 2025 Jan 21;6(1):101887.(IF:10/Q1)

18.Zhang Z, Fan B, Zhou C, Zhang P, Liu C, Xiang Y, Xia W, Sun G, You Y, Li D, Xu J, Huang J, Huang C*. Biomimetic Selenium-Nanocomposites Alleviate MASH by Modulating Lipid and Iron Homeostasis. Adv Healthc Mater. 2025 Jun 5:e2500467. (IF:10/Q1)

四、获奖成果

1、湖北省科技进步奖，功能性富硒资源创新研究及产业应用，三等奖，2024，第1。

2、李四光地质成果奖，恩施州不同硒镉背景区硒镉等元素生态效应评价，三等奖，2024，第2。

五、授权发明专利

1、黄楚鹰，王莉.硒蛹虫草水提物的应用,专利号:ZL202110692940.1

2、吕鹏黄楚鹰赖琳.一种中药组合物在化疗神经病理性疼痛中的应用，专利号：ZL202310326126.7