姓 名: 胡家新(土家族);
联系电话:18805152985;
电子邮件:hjxlmy@outlook.com;
通讯地址: 湖北省恩施市金龙大道199号 硒资源研究与生物应用湖北省重点实验室;
任职情况:博士,恩施州中心医院内科心血管病中心 主治医师 主任助理,硒资源研究与生物应用湖北省重点实验室PI;
研究领域:1.动脉粥样硬化及动脉瘤发病机制的探索极其相关药物的筛选 2.心血管药物靶向递送新型材料的研发与应用;
一、学习和工作简历:
学习经历:
2010/09 - 2015/07,湖北民族大学,临床医学专业,获医学学士学位;
2016/09 - 2019/07,南京大学,临床医学专业,获医学硕士学位;
2019/09 - 2022/07,南京大学,临床医学专业,获医学博士学位;
工作经历:
2022/09-至今,恩施州中心医院内科心血管病中心 主治医师 主任助理;
2023/03-至今 ,硒资源研究与生物应用湖北省重点实验室PI;
2023/06-至今,湖北民族大学,医学院,硕士生导师;
2025/06-至今,湖北民族大学,生工院,硕士生导师;
二、承担科研项目情况:
1、国家自然科学基金青年项目(C类),NREP经hnRNPA1介导PKM2剪切调控VSMC表型转换在腹主动脉瘤中的作用与机制研究,项目编号82400566,经费60万元,2025-2027,主持。
2、湖北省自然科学基金青年项目,糖尿病背景下PKM2表达下调致VSM代谢重编程经Glycine-GARS-GlytRNA抑制腹主动脉瘤形成的机制研究,项目编号2023AFB127,经费16万元,2023-2025,主持。
3、恩施州科技局项目,靶向递送SeMet治疗心血管疾病新型材料的研发与应用,项目编号D20230072,经费40万元,2023-2025,主持。
4、恩施州中心医院科研创新团队,经费90万元,2025-2028,主持。
三、代表性论文
1、Jiaxin Hua #, Yuyu Lia #, Zhonghai Weia #, Haiting Chena, Xuan Suna, Qing Zhoub, Qi Zhang a, Yong Yina, Meng Guoa, Jianzhou Chena, Guangyao Zhaic, Biao Xua *, Jun Xiea * ;A Reduction in the Vascular Smooth Muscle Cell Focal Adhesion Component Syndecan-4 is Associated with Abdominal Aortic Aneurysm Formation;Clinical and Translational Medicine(中科院1区,IF=11.492)
2、Jiaxin Hu† , Ying Zhang† , Liaoping Hu† , Haiting Chen† , Han Wu, Jianzhou Chen, Jun Xie, Biao Xu* and Zhonghai Wei*;A reduction of Syndecan-4 in macrophages promotes atherosclerosis by aggravating the proinfammatory capacity of macrophages;Journal of Translational Medicine(中科院2区TOP,IF=8.5)
3、Jinxuan Zhaoa #; Xueling Lib #; Jiaxin Hua #; Fu Chena; Shuaihua Qiaoa; Xuan Suna; Ling Gaoa; Jun Xiea *; Biao Xua *;Mesenchymal Stromal Cell-Derived Exosomes Attenuate Myocardial Ischemia-Reperfusion Injury through miR-182-Regulated Macrophage Polarization;Cardiovascular Research(中科院1区TOP,IF=14.239)
4.Jiamin Xu1†, Jiling Zhao2†, Haiting Chen5†, Xi Tan4†, Wenfeng Zhang1,Zhongnan Xia2, Dejiang Yao6, Yuhua Lei2*, Biao Xu1*, Zhonghai Wei1* and Jiaxin Hu2,3*;Mesenchymal stromal cell-derived exosomes protect against abdominal aortic aneurysm formation through CD74 modulation of macrophage polarization in mice;Stem Cell Research & Therapy(中科院2区TOP,IF=7.1)
5.Jiaxin Hu a, bc, 1, Jiamin Xu b, 1, Jiling Zhao a, 1, Yuwei Liu d, 1, Rui Huang a, Dejiang Yao e, Jun Xie f, **,Yuhua Lei a, *;Colchicine ameliorates short-term abdominal aortic aneurysms by inhibiting the expression of NLRP3 inflammasome components in mice;European Journal of Pharmacology(中科院2区,IF=5.0)
6.Jiaxin Hua #, Song Shena #, Jiamin Xua #, Wengfeng Zhangb, Haiting Chena, Xuan Suna, Yu Qia, Ying Zhanga,Yuyu Lia, Qi Zhang a, Meng Guoa, Ningxin Pengb,Biao Xua *; Trimethylamine N-oxide promotes abdominal aortic aneurysm formation by enhancing the aortic smooth muscle cells senescence in mice;Journal of Cardiovascular Translational Research(中科院2区,IF=4.3)
7.Jiaxin Hu1,2 ,Jiamin Xu2 ,Xi Tan3 ,Dong Li4,Dejiang Yao5,Biao Xu3,Yuhua Lei1;Dapaglifozin protects against dilated cardiomyopathy progression by targeting NLRP3 infammasome activation;Naunyn-Schmiedeberg's Archives of Pharmacology(中科院4区,IF=3.6)
8.Yafei Shia,b,1 , Jiaxin Huc,1 , Jin Gengb,1 , Tingting Hub , Bingjian Wangb , Wenting Yanb , Yicheng Jiangb , Jiangjin Lib , Shaowen Liua,⁎; Berberine treatment reduces atherosclerosis by mediating gut microbiota in apoE-/- mice;Biomedicine & Pharmacotherapy(中科院2区,IF=7.419)